Cancer progression is driven by a series of biological capabilities known as the Hallmarks of Cancer. Two of the most critical hallmarks are the ability of tumour cells to resist cell death and sustain continuous proliferative signalling. Together, these mechanisms allow cancer cells to survive beyond their normal lifespan and continue dividing uncontrollably.
We support researchers, diagnostic laboratories, and oncology professionals with advanced solutions from Cell Signaling Technology (CST) for investigating these complex cancer pathways.
Resisting Cell Death
Under normal physiological conditions, damaged or abnormal cells undergo programmed cell death, known as apoptosis, to maintain tissue homeostasis. Cancer cells disrupt these mechanisms, allowing survival despite DNA damage, oncogenic stress, or therapeutic intervention.
Key mechanisms involved include:
- Disruption of the intrinsic mitochondrial apoptosis pathway
- Increased expression of anti-apoptotic proteins such as BCL 2 and Mcl-1
- Reduced expression of pro-apoptotic proteins, including BAX and BAK
- Evasion of alternative cell death mechanisms such as ferroptosis, necroptosis, and pyroptosis
Critical markers and targets associated with apoptosis research include:
- Caspase 3, Caspase 8, and Caspase 9
- Cleaved PARP and DFF45
- Cytochrome c and Apaf 1
- BCL 2 family proteins
- XIAP, Survivin, and Livin
- Ferroptosis markers, including xCT/SLC7A11 and ACSL4
- Necroptosis regulators RIPK1, RIPK3, and MLKL
Advanced Research Tools from CST
CST provides highly validated antibodies, assays, and pathway specific solutions designed to support cancer biology research across multiple applications.
Featured solutions include:
Apoptosis Assays
Reliable tools for detecting early and late stage apoptosis, including Annexin V FITC Early Apoptosis Kits and TUNEL assays.
Proliferation Markers
IHC validated antibodies for identifying proliferative activity and pathway activation in tissue samples.
Single Cell Analysis with InTraSeq™
Advanced single cell analysis technology enabling simultaneous measurement of RNA expression and intracellular signalling proteins such as P ERK and P Akt within the same cell population.
Pathway Specific Sampler Kits
Comprehensive antibody sampler kits for targeted pathway analysis, including:
- PI3K/Akt signalling panels
- MAPK/ERK signalling panels
- Pro Survival BCL 2 Family Antibody Sampler Kits
Supporting Cancer Research with Precision
Understanding the signalling pathways that drive tumour survival and proliferation is essential for advancing cancer diagnostics, therapeutic development, and translational research. CST solutions help researchers move beyond traditional single-target analysis toward deeper pathway interrogation and multiplexed cellular insights.
For more information on CST cancer research solutions, complete the form below.