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  • The new world of GCMS is here with the Q Exactive GC Obitrap system

    The new world of GCMS is here with the Q Exactive GC Obitrap system
    25 May 2016

    Anatech Instruments is excited to announce the release of the new Thermo Scientific Q Exactive GC hybrid quadrupole-Orbitrap GC-MS/MS instrument.
    This new GCMS/MS was launched at the 63rd Annual American Society for Mass Spectrometry Conference in St. Louis at the beginning of June 2015. Thermo Scientific has unlocked the power of Orbitrap technology for gas chromatography providing users.
    The new Thermo Scientific Q Exactive GC hybrid quadrupole-Orbitrap GC-MS/MS instrument represents the first-ever commercial system offering a combination of gas chromatography and HRAM Orbitrap mass spectrometry. This system is designed to provide the comprehensive characterization of samples in a single analysis for increased performance in compound discovery, identification and quantitation.
    Laboratories performing food safety and authenticity, pharmaceutical, metabolomic, antidoping and other analyses using gas chromatography-mass spectrometry (GC-MS) can now achieve new levels of performance using high-resolution accurate-mass (HRAM) Orbitrap mass spectrometry, bringing the highest level of detection and identification capabilities to GC-MS studies.
    This system brings together qualitative and quantitative analyses by combining the high-precision, full scan HRAM capability of Orbitrap technology with the quantitative power of GC triple quadrupole technology. The system builds upon the flexible modularity of the Thermo Scientific TRACE 1300 Series GC, including user-exchangeable injectors and detectors.
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    The scientific world is very excited as world renowned scientist have been quoted at the unveiling at ASMS 2015:
    Professor Joshua Coon, PhD, University of Wisconsin, Madison, applies GC-MS to metabolomic studies to understand complex biological systems. “While the LC-MS field has advanced rapidly over the past several years, largely driven by the impact of the Orbitrap mass analyzer, GC-MS could not offer comparable mass resolution and accuracy,” said Dr. Coon. “The introduction of the Q Exactive GC system is a game changer in this space. The combination of fast, predictable GC separations with accurate mass capabilities will translate to an increased ability to profile entire metabolomes.”
    In laboratory tests, the Q Exactive GC system has shown quantitative capability equivalent to high-performing GC-MS triple quadrupole systems, especially when comparing analytical parameters such as sensitivity, precision and linearity. This technology is designed to advance chemical analyses within laboratories limited by currently available full scan GC-MS technologies, such as time-of-flight (TOF) and quadrupole-time-of-flight (Q-TOF) mass spectrometry, or comparable technologies. Thermo Fisher Scientific expects the Q Exactive GC system will be useful for untargeted profiling experiments because it can add new capabilities to screening in food safety, forensic toxicology and anti-doping.
    As the creator of Orbitrap Dr. Alexander Makarov, Director of Research, Life Science Mass Spectrometry at Thermo Fisher Scientific has said: “GC Orbitrap technology significantly expands the firepower of GC-MS, which will spark an acceleration in discovery for small molecule analysis across multiple applications.”
    Should you require additional information on the Q Exactive GC system, please contact Corlien Bezuidenhout at 011 462–6776/079 872 6456 or corlien@anatech.co.za.

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